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Indications and Dosage
Oral
Pain and inflammation associated with musculoskeletal and joint disorders Adult: 250 mg 3 or 4 times daily. Max: 1500 mg daily. Topical/Cutaneous Pain and inflammation associated with musculoskeletal and joint disorders Adult: 3% cream or ointment or 2.5% gel to be applied to affected areas.
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Administration
Should be taken with food. Take w/ or immediately after meals.
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Contraindications
Active peptic ulceration, severe heart failure.
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Special Precautions
Discontinue if hypersensitivity skin reactions occur. Pregnancy, lactation. Elderly, patients with haemorrhagic disorders; hypertension; impaired renal, hepatic, cardiac function; asthma; infections; left ventricular failure; oedema; history of CHF.
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Adverse Reactions
CNS disturbances, hypersensitivity reactions, renal/hepatic disorders, GI disturbances, cutaneous reactions, agranulocytosis, neutropenia. Fluid retention, photosensitivity, alveolitis, pulmonary eosinophilia, pancreatitis, Stevens-Johnson syndrome, exacerbation of colitis.
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Drug Interactions
May increase concentration of methotrexate, cardiac glycosides. Increased risk of nephrotoxicity with ACE inhibitors, ciclosporin, tacrolimus, diuretics. Increased risk of GI bleeding with corticosteroids, SSRIs, venlafaxine, clopidogrel, ticlopidine, iloprost, erlotinib, sibutramine, alcohol, bisphosphonates, pentoxifylline.
Potentially Fatal: May reduce lithium excretion leading to lithium toxicity. May increase effects of anticoagulants. |
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Action
Description: Niflumic acid is an NSAID derived from nicotinic acid.
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